This work began within our Johns Hopkins Bowel Tumor Working Group (since 1986) and from the multidisciplinary Pancreatic Cancer Working Group (since 1991).В OurВ SPORE program was the first to sequence a cancer genome, the first to demonstrate that exome sequencing can identify the cause of a hereditary disease and the first to show immunotherapy is an effective treatment for micro-satellite unstable cancers. Throughout the 26 year history of our SPORE program we have transformed the understanding of the how and why these cancers develop and used the knowledge to improve detection and treatment for these cancers. This work is coupled with cutting-edge therapeutic advances for patients who develop these cancers. Our SPORE program is dedicated to understanding molecular underpinnings of these cancers and translating these findings to improve risk assessment and early detection screening for these cancers. To serve as an organizational foundation enabling and encouraging the best team scienceД¬olorectal and pancreatic cancers represent the 2nd and 3rd leading causes of cancer deaths respectively in the United States.To provide a strong scientific basis for efficient cancer research.Aid the decision-making of patients and families ranging from individual.Reduce cancer incidence and mortality of gastrointestinal cancers.The focus of Johns Hopkins GI SPORE program is to: This program has been continuously funded through the NCI Translational Research Program. The Specialized Program of Research Excellence (SPORE) in Gastrointestinal Cancer at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins supports a highly interactive, multidisciplinary program of Gastrointestinal Cancer Researchers.

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